Transfusion Criteria for Fresh Frozen Plasma in Liver Resection

Transfusion criteria for fresh frozen plasma in liver resection: a 3 + 3 cohort expansion study.

OBJECTIVE To establish transfusion criteria for use of fresh frozen plasma (FFP) in liver resection. BACKGROUND Fresh frozen plasma has been transfused in liver resection without adequate supporting evidence, leading to unnecessary use. DESIGN Prospective study using a phase 1 dose-escalation, 3 + 3 cohort expansion design, modified for FFP transfusion. We designated a serum albumin level o...

Negative impact of fresh-frozen plasma transfusion on prognosis after hepatic resection for liver metastases from colorectal cancer.

BACKGROUND In perioperative management of hepatic resection for colorectal cancer liver metastasis (CRLM), excessive blood loss and blood transfusion greatly influence postoperative complications and prognosis of the patients. We evaluated the influence of the use of blood products on prognosis of patients with CRLM. PATIENTS AND METHODS The subjects of this study were 65 patients who underwe...

Coagulation and Transfusion Medicine / RATIONAL FRESH FROZEN PLASMA TRANSFUSION Toward Rational Fresh Frozen Plasma Transfusion The Effect of Plasma Transfusion on Coagulation Test Results

Numerous published guidelines encourage appropriate use of fresh frozen plasma (FFP). However, adherence is documented as poor. Therefore, we sought to determine the laboratory effect of FFP administration to patients with an international normalized ratio (INR) less than 1.6 (prothrombin time <1.6 times normal). We found minimally prolonged INRs decreased with treatment of the underlying disea...

Photochemically treated fresh frozen plasma for transfusion of patients with acquired coagulopathy of liver disease.

An ex vivo photochemical treatment (PCT) process was developed to inactivate pathogens in fresh frozen plasma (PCT-FFP). A prospective, controlled, double-blinded, randomized study was conducted to evaluate the efficacy and safety of PCT-FFP compared with conventional FFP (C-FFP). Patients (n = 121) with acquired coagulopathy, largely due to liver disease, including hepatic transplantation, wer...

Pulmonary oedema after transfusion with fresh frozen plasma.